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A “theoretical” postmortem redistribution factor (Ft) as a marker of postmortem redistribution

Iain M. McIntyre.

Cited by (1)

Abstract
Postmortem redistribution (PMR) refers to the changes that can occur in drug concentrations after death. Literature supports a model describing drugs with a liver (L) to peripheral blood (P) concentration (L/P) ratio less than 5 L/kg as being prone to little or no PMR, while drugs with a L/P ratio greater than 20-30 L/kg have propensity for substantial PMR. Additionally, the concept of a postmortem redistribution (F) factor has been recently described to express the direct relationship between postmortem peripheral blood and the corresponding antemortem whole-blood concentration. The current document expounds upon both these concepts by proposing the development of a “theoretical” postmortem redistribution factor (Ft ) for a drug––based upon a drug’s characteristic L/P ratio. This model for estimating potential of PMR was produced to assist with a credible interpretation of postmortem drug concentrations.

Key words: Forensic sciences, forensiic toxicology, postmortem redistribution factor (F), peripheral blood, liver, antemortem


 
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REFERENCES
1. Pounder DJ, Jones GR. Post-mortem drug redistribution – A toxicological nightmare. Forensic Sci Int 1990;45:253-63. [DOI via Crossref]   
2. Hilberg T, Ripel A, Slørdal L, Bjørneboe A, Mørland J. The extent of postmortem drug redistribution in a rat model. J Forensic Sci 1999;44:956-62. [DOI via Crossref]    [Pubmed]   
3. Drummer OH. Postmortem toxicology of drugs of abuse. Forensic Sci Int 2004;142:101-13. [DOI via Crossref]    [Pubmed]   
4. McIntyre IM, Sherrard J, Lucas J. Postmortem carisoprodol and meprobamate concentrations in blood and liver: Lack of significant redistribution. J Anal Toxicol 2012;36:177-81. [DOI via Crossref]    [Pubmed]   
5. McIntyre IM. Liver and peripheral blood concentration ratio (L/P) as a marker of postmortem drug redistribution: A literature review. Forensic Sci Med Pathol 2014;10:91-6. [DOI via Crossref]    [Pubmed]   
6. McIntyre IM, Nelson CL, Schaber B, Hamm CE. Antemortem and postmortem methamphetamine blood concentrations: Three case reports. J Anal Toxicol 2013;37:386-9. [DOI via Crossref]    [Pubmed]   
7. McIntyre IM. Identification of a postmortem redistribution factor (F) for forensic toxicology. J Anal Sci Technol 2014;5:24. [DOI via Crossref]    s40543-014-0024-3.
8. Committee on Medicolegal Problems, Alcohol and the Impaired Driver. American medical association, Chicago (1970) 18-19, presented. In: Baselt RC, editor. Disposition of Toxic Drugs and Chemicals in Man. 10th ed. Seal Beach, California, USA: Biomedical Publications; 2014. p. 981-5.
9. Pélissier-Alicot AL, Gaulier JM, Champsaur P, Marquet P. Mechanisms underlying postmortem redistribution of drugs: A review. J Anal Toxicol 2003;27:533-44. [DOI via Crossref]    [Pubmed]   
10. Gerostamoulos D, Beyer J, Staikos V, Tayler P, Woodford N, Drummer OH. The effect of the postmortem interval on the redistribution of drugs: A comparison of mortuary admission and autopsy blood specimens. Forensic Sci Med Pathol 2012;8:373-9. [DOI via Crossref]    [Pubmed]   

This Article Cited By the following articles

Analytical data supporting the “theoretical” postmortem redistribution factor (Ft): a new model to evaluate postmortem redistribution
Forensic Sciences Research 2016; 1(1): 33.

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How to Cite this Article
Pubmed Style

Iain M. McIntyre. A “theoretical” postmortem redistribution factor (Ft) as a marker of postmortem redistribution. Eur J Forensic Sci. 2015; 2(4): 24-26. doi:10.5455/ejfs.181615



Web Style

Iain M. McIntyre. A “theoretical” postmortem redistribution factor (Ft) as a marker of postmortem redistribution. www.scopemed.org/?mno=181615 [Access: October 20, 2017]. doi:10.5455/ejfs.181615



AMA (American Medical Association) Style

Iain M. McIntyre. A “theoretical” postmortem redistribution factor (Ft) as a marker of postmortem redistribution. Eur J Forensic Sci. 2015; 2(4): 24-26. doi:10.5455/ejfs.181615



Vancouver/ICMJE Style

Iain M. McIntyre. A “theoretical” postmortem redistribution factor (Ft) as a marker of postmortem redistribution. Eur J Forensic Sci. (2015), [cited October 20, 2017]; 2(4): 24-26. doi:10.5455/ejfs.181615



Harvard Style

Iain M. McIntyre (2015) A “theoretical” postmortem redistribution factor (Ft) as a marker of postmortem redistribution. Eur J Forensic Sci, 2 (4), 24-26. doi:10.5455/ejfs.181615



Turabian Style

Iain M. McIntyre. 2015. A “theoretical” postmortem redistribution factor (Ft) as a marker of postmortem redistribution. European Journal of Forensic Sciences, 2 (4), 24-26. doi:10.5455/ejfs.181615



Chicago Style

Iain M. McIntyre. "A “theoretical” postmortem redistribution factor (Ft) as a marker of postmortem redistribution." European Journal of Forensic Sciences 2 (2015), 24-26. doi:10.5455/ejfs.181615



MLA (The Modern Language Association) Style

Iain M. McIntyre. "A “theoretical” postmortem redistribution factor (Ft) as a marker of postmortem redistribution." European Journal of Forensic Sciences 2.4 (2015), 24-26. Print. doi:10.5455/ejfs.181615



APA (American Psychological Association) Style

Iain M. McIntyre (2015) A “theoretical” postmortem redistribution factor (Ft) as a marker of postmortem redistribution. European Journal of Forensic Sciences, 2 (4), 24-26. doi:10.5455/ejfs.181615



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